![]() Thus, while these vaccines have proven to be remarkably effective, rare cases of anaphylaxis have been reported, and this has been tentatively ascribed to the PEGylated carriers, which may trigger complement activation in susceptible individuals. The increased use of nanoparticles as contrast agents or in drug delivery, along with the introduction of mRNA vaccines encapsulated in PEGylated lipid nanoparticles has brought this issue to the fore. PEG is viewed as being well-tolerated, but previous studies have identified anti-PEG antibodies and so-called pseudoallergic reactions in certain individuals. PEGylation refers to the conjugation of PEG to drugs or nanoparticles to increase circulation time and reduce unwanted host responses. Poly (ethylene glycol) (PEG) is a widely used polymer in a variety of consumer products and in medicine. 6School of Chemical and Process Engineering, University of Leeds, Leeds, United Kingdom.5Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.4Institute of Occupational Medicine, Edinburgh, United Kingdom.2Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.1Department of Chemistry, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland.Esperanza Padín-González 1 Pearl Lancaster 1 Massimo Bottini 2 Paolo Gasco 3 Lang Tran 4 Bengt Fadeel 5 Terence Wilkins 6* Marco P. ![]()
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